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Damage of this type affects aconitase and isopropylmalate isomerase, for example, and thereby impairs the TCA cycle and the synthesis of branched-chain amino acids (Jang and Imlay, 2007)

These alterations reduce ATP production, increase oxidative damage, and render neurons more vulnerable to metabolic stress

It follows that iron metabolism and mean cell hemoglobin concentration, as well as genetic or other factors regulating them, such as blood donation frequency or repletion 74 , could contribute to inter-donor heterogeneity in hemolytic propensity and RBC susceptibility to hemolysis in general, making our findings relevant beyond transfusion medicine

Radiotherapy plays a pivotal role in controlling and eradicating tumors as an adjuvant cancer treatment, either alone or in combination with other modalities (surgery, chemotherapy, immunotherapy and targeted therapy) (143)