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Collectively, the combination of treatment based on PDT, SDT, and CDT promoted the accumulation of highly poisonous 1 O 2 and OH, thus producing a drastically powerful anticancer effect

Furthermore, NPs can be engineered to mimic endogenous transport mechanisms, like those used by nutrients or hormones, to cross the BBB more effectively (22)

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Offering alternative injection sites is expected to provide additional flexibility to patients, potentially improving adherence and satisfaction, particularly for those who may prefer less visible or more convenient injection locations