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Reactive astrocytes exacerbate inflammation by releasing additional cytokines, contributing to a feedback loop that worsens neuronal injury ( The interaction between excitotoxicity and neuroinflammation is critical for the development of long-term neurodegeneration

mPSCs were measured under 500 nM tetrodotoxin (TTX, Tocris) in combination with either 5 M 1( S ),9( R )-()-Bicuculline methiodide (Bicuculline, Sigma) for pharmacologically isolated excitatory recordings, or 10 M 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, Sigma) for inhibitory recordings

Standard cycling involves 4-8 weeks of use followed by 2-4 weeks off before resuming if needed

The combined action of these mechanisms endows the N/Se-CNF electrode with a high specific capacitance of 268 F g 1 at 0.2 A g 1 , 60% capacity retention at a high rate of 20 A g 1 , and 88.1% capacity retention after 18,000 cycles at 5 A g 1