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To account for differences in the duration of vision loss at the time gene therapy was administered, a locally estimated scatterplot smoothing (LOESS) nonparametric local regression model was used to independently assess each patients eyes beginning 12 months after the onset of vision loss, when 92.7% of eyes (139/150) had received treatment

We isolated the frontoparietal cortex of the ischemic animals, in which, according to histological analysis of our earlier research, the damaged area was localized [51]