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A significant driver of dysautonomia is small fiber neuropathydamage to the tiny, unmyelinated or thinly myelinated nerve fibers that control involuntary autonomic functions like heart rate, blood pressure, and digestion

doi:10.1093/brain/awr128

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The similarity of some aspects of the inhibition of the mitochondrial transporter with those previously found for the plasma membrane OCTN2 transporter, which however were not described at the molecular level [19], indicates that the substrate binding sites should have some similar properties, in spite of the very different primary structures and affinity for substrates of the two proteins