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doi: 10.1016/j.redox.2023.102604, 73 KalsbeekM

(2024) 10:e34799

Alisertib, an aurora kinase A/B inhibitor, has shown tumor suppression in SCLC cells with variant ASCL1 and MYC amplification in preclinical studies ( via immunohistochemistry, patients with positive MYC expression had significant benefit in progression free survival, while the patients with MYC negative expression actually had worse outcomes when alisertib was added to paclitaxel ( ONC201: A Promising Novel Agent for SCLC There are currently over 275 clinical trials registered with the FDA in SCLC that are active or recruiting patients for study