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Komaki R, Roth JA, Walsh GL, Putnam JB, Jr, Swisher SG , Vaporciyan AA, Lee JS, Fossella F, Chasen M, Cox JD

Albuterol is longer acting than isoproterenol in most patients by any route of administration because it is not a substrate for the cellular uptake processes for catecholamines or for COMT Less than 20% of a single albuterol dose is absorbed systemically following nebulizer administration Albuterol does not readily cross the blood brain barrier Bronchodilation is maximal in ~15 minutes, and persists for 3-4 hours

However, the body's ability to produce it can be hampered by factors like poor diet, environmental pollutants, and the natural ageing process

10.1016/j.taap.2023.116694 3 CaoX