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Recently, studies have provided convincing evidence that histone lysine methylation can be reversed, thereby providing an additional level of control

One feedback loop affecting Clk mRNA cycling is mediated by VRILLE (VRI) and PAR DOMAIN PROTEIN 1 expression 10,11 , and another is mediated by CLOCKWORK ORANGE (CWO), which is activated by CLK-CYC 12,13,14,15