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In ACLY -knockout cell lines, the addition of exogenous acetate at physiological blood concentrations sustained acetyl-CoA levels and lipogenic metabolites via ACSS2 induction, suggesting that circulating acetate is likely adequate for compensatory lipid synthesis 80,105

Enrichment analysis of CD8 + T cells demonstrated upregulation of ligand-receptor signaling, T cell activation, chemokine, cytokine, and intracellular signal transduction (Fig

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