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QSAR quantitative structure-activity relationship D-Nle- Tyr-ile-NH-(CH 2 )5-CONH 2 was predicted to be orally bioavailable

Children may be given a total of 1 to 5 mg over a period of 2 or more weeks in doses of 100 mcg, then 30 to 50 mcg every 4 weeks for maintenance

In these studies, Epithalon administration in elderly or immunosuppressed animals leads to increased production of thymic peptides and improved immunological parameters, including CD4/CD8 ratios and natural killer (NK) cell activity [3]

1 H NMR (400 MHz, chloroform- d ) 7.327.24 (m, 3H), 7.237.15 (m, 2H), 3.62 (t, J = 5.2 Hz, 2H), 3.503.43 (m, 2H), 2.692.61 (m, 2H), 2.462.34 (m, 6H), 2.08 (s, 3H), 1.82 (p, J = 7.6 Hz, 2H)