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Glutaminase is also essential to cancer cell aggressiveness, including cell migration and invasion processes 15,46,66

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Main text Mechanisms of Mn uptake into the CNS As Mn is required for multiple cellular events but becomes toxic at high levels, the intracellular Mn concentration has to be under strict control

The primary endpoint was the cough-specific quality of life measured by the Cough Quality of Life Questionnaire (CQLQ) and results showed that Thal improved cough and respiratory quality of life in IPF patients (Horton et al., 2012) (ClinicalTrials.gov Identifier: NCT00600028) Summarized in Table 4