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In a murine model of B16F10 melanoma expressing both VEGF-C and chicken ovalbumin (OVA), overexpression of VEGF-C in cancer cells promotes lymphangiogenesis in both primary tumors and TDLNs, leads to CD8+ T cell immune tolerance via LEC cross-presentation ( Figure 1 ), protects tumors against preexisting anti-cancer immunity, and promotes the local elimination of OVA-specific CD8+ T cells (93)

Further studies revealed that Nrf2 knockdown had an activating effect on STAT3, suggesting that Nrf2 and STAT3 co-regulate SLC7A11 to reduce ferroptosis and protect against IIR-ALI

This is particularly true among sulfur-containing residues such as methionine and cysteine

PMID 16128682