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Tumor necrosis factor- expressed constitutively in erythroid cells or induced by erythropoietin has negative and stimulatory roles in normal erythropoiesis and erythroleukemia

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This often occurs in smokers, people with metabolic disease, heavy alcohol drinkers, as a side effect of certain prescription drugs, rheumatoid arthritis and impaired thyroid function

Adverse Effects Adverse effects are classified as Very Frequently: 10% or more, Frequently : 1% or more ~ less than 10%, Sometimes: 0.1% or more ~ less than 1 %, Rarely: 0.01 % or more ~ less than 0.1%, and Very Rarely: less than 0.01% based on the frequency of the effects