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10.1016/j.freeradbiomed.2016.06.005 14 AngelovaP

We then tested whether other agents that specifically caused nucleotide imbalance (rather than the DNA-driven and RNA-driven effects of 5FU) have the same mechanism of action

From these data it can be calculated that each gram of glycerol added to 100 g of tobacco increases the acrolein emission per cigarette by about 0.9 g ( r 2 = 0.96)

Owing to higher proliferative demands, cancer cells have higher basal ISR levels as compared to normal cells, thus any additional perturbations heighten the ISR bringing the cell closer to the apoptotic threshold (115)