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This is especially common for vegetarians, older adults, and those with absorption issues

The incidence of renal failure in clinical studies in which patients received pemetrexed as a single agent ranged from 0.4% to 0.6% (Studies JMEN, PARAMOUNT, and JMEI [see Adverse Reactions (6.1)]

The fit of the constant area of $\Gamma /q^3$ is plotted as a solid line with an error band highlighting the standard error of those fits in Fig

5.8.2.2 Comparison of dicobalt edetate with other compounds A number of research groups have compared cobalt edetate with other cyanide antidotes, from the point of view both of antidotal efficacy (Table 4) and also of toxicity