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Studies have shown that FIN56 can significantly reduce the survival rate of GBM cells (such as LN229 and U118 cells) by inducing ferroptosis, increasing lysosomal membrane permeability, inhibiting cell proliferation, and causing cell cycle arrest

On the other hand, this toxicity response to AFB 1 is proven by a significant increase in LDH and cardiac troponins leakage from BCMs, as sensitive markers for acute cardiac damage (133)

How these variations impact systemic BA pools and the immune landscape of tumors, particularly those within the hepatobiliary-pancreatic system, and potentially extending to extra-intestinal sites where preliminary associations with BA exposure have been noted (190), needs to be clarified

The exact number can vary based on factors like your skin type, age, and the specific concerns you're treating