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Interestingly, a study found that mutations in CHCHD2 in fibroblasts from PD patients lead to fragmentation and reduced OXPHOS activity of complexes I and IV [104]

Many outcomes such as health related quality of life and mortality are important to all kidney diseased patient populations and therefore can be translated to the AKI setting

Ameliorated concanavalin A-induced autoimmune hepatitis in mice by reprofiling gut microenvironment to modulate IDO1/KYN and PI3K/AKT/NF-B pathways

We then unveiled how the mutation affects endothelial progenitor cells and impacts angiogenesis and endothelial stability, revealing how the liver niche plays a significant role in ALGS-related liver disease and explaining some of the systemic manifestations of the syndrome