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Patients with Chronic Pulmonary Disease Acetaminophen and codeine phosphate tablets-treated patients with significant chronic obstructive pulmonary disease or cor pulmonale, and those with a substantially decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression are at increased risk of decreased respiratory drive including apnea, even at recommended dosages of acetaminophen and codeine phosphate tablets [see WARNINGS

10.1002/qub2.34 399 YangY.TangL.XiaoY.HuangW.GaoM.XieJ.et al (2024b)

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186,187 Rare inactivating mutations in CBP and PCAF have only been identified in cancer cell lines but not primary tumors