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The clinical use track record in Eastern Europe and Asia provides a level of real-world safety and efficacy data that purely preclinical peptides lack, though large-scale randomized controlled trials specifically for peripheral neuropathy are still needed

ARA-290 has the strongest specific evidence for SFN, with human clinical trials demonstrating measurable nerve fiber regrowth in the cornea of SFN patients

Some patients report noticeable improvements in pain, mobility, and function within 2 to 4 weeks, while others can take up to 12 weeks or longer to see measurable progress

This interaction is crucial for fibroblast recruitment and activation, leading to ECM remodeling