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The FDA moved these peptides to Category 2 primarily due to a lack of large-scale, randomized, placebo-controlled human trials demonstrating their safety and efficacy

These organoselenium compounds demonstrate potent anticancer and chemopreventive properties by engaging a multitude of action mechanisms including reduction of oxidative stress, induction of apoptosis, and enhancement of chemotherapeutic drug activity (218221)

Finally, we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field

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