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The normal amount stored is 2-3mgs in adults, which is sufficient for 2 to 4 years

Targeting metabolism to enhance immunotherapy by relieving metabolic suppression of T cells represents a promising direction, but requires careful balance to avoid inadvertently impairing anti-tumor immunity

S8D), H82 and H526 exhibited the highest NRF2 protein levels upon KEAP1 inhibition along with marked upregulation of the NRF2 target genes NQO1 and AKR1C3 , indicating that the NRF2 regulon is functional in those two cell lines (Fig