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Description

18 MBDs recruit histone-modifying and chromatin-remodelling complexes to methylated sites, thereby forming compact, inactive heterochromatin

The landmark study from 1992, The Beaver Dam Study, provided one of the first estimates of the prevalence of features of maculopathy including soft drusen, pigmentary abnormalities, choroidal neovascularization, and geographic atrophy, over a broad spectrum of ages (Klein et al., 1992)