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However, intraperitoneal injection of TAK-242, an inhibitor of TLR4, protects tubular cell injury by suppressing GSDMD-related pyroptosis in db/db mice, and the expression of caspase-1 and GSDMD-NT were significantly decreased in renal cortex tissue (127)

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This pathway is exquisitely sensitive to molecular structure

This is confirmed in Table 8, which also shows that the two commercial tools show high concordance with DataWarrior in terms of the number of predictions within 2 pKa units error