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There is some evidence that an injection of local anaesthetic and steroid can help those who do not respond to the 4 Rs or have an underlying metabolic issue, but a simple injection will not correct the primary cause of the nerve compression

As with any wellness intervention, it works best as part of a comprehensive program that includes healthy nutrition and regular physical activity

In streptozotocin (STZ)-induced type I diabetic rats, kidney COX-2 protein expression is increased (Cheng et al., 2002)

In addition, probiotics can regulate the activity of immune cells, including T cells and macrophages, contributing to a balanced immune response that protects the BBB (Rastogi and Singh, 2022)