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Nutrition and Metabolism of Dogs and Cats

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Regarding SLC transporters, reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), organic anion transporter 3 (OAT3), and organic anion transporting polypeptide 1A2 (OATP1A2) all transport MTX as a substrate (Badagnani et al

Strategies to minimize reactions include rotating injection sites consistently to avoid repeated trauma to the same area, ensuring the solution is at room temperature before injection (cold injections can increase irritation), injecting slowly rather than quickly, and using a smaller gauge needle for less tissue trauma