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Because activated CD8+ T-cells depend on sustained glycolysis, excess extracellular lactate disrupts lactate efflux, leading to intracellular acidification and metabolic dysfunction that blunt T-cell activity within the GBM TME

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Pf Prx1a, located in the cytosol, belongs to the typical 2-Cys Prx family with its peroxidatic cysteine at position C50 and its resolving cysteine at position C170

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Steven Galetta, chairman of neurology at NYU Langone Medical Center in New York City

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