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[268] It is envisaged that the composition of the invention might comprise, in addition to the polypeptide of the invention defined herein, further biologically active agents, depending on the intended use of the composition

As mentioned previously, the lactylation of RIG-I at K852 promotes liver metastasis in CRC

Auto-immune acanthosis nigricans It is due to the development of antibodies to insulin receptors in autoimmune diseases such as systemic lupus erythematosus.[9] Acral acanthosis nigricans (acralacanthotic anomaly) It occurs in otherwise healthy patients

This is a reasonable position, and it is one of the arguments the July panel will need to weigh carefully against the absence of rigorous human trial data