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In contrast, cancer cells with high levels of SLC7A11 (SLC7A11 high ) have been observed to accumulate intracellular cystine when glucose levels are low, draining the cellular NADPH pool and leading to the aberrant accumulation of intracellular disulfides and subsequently to disulfidptosis, a previously uncharacterized form of cell death that differs from apoptosis and ferroptosis[89, 90]

both of which will result in lens transparency loss (14)

4c, e, Supplementary Table 2) we were able to trace the nascent polypeptide from the P-site tRNA until it reaches NMT1 (Fig

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