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PRIMA-1MET induces apoptosis through accumulation of intracellular reactive oxygen species irrespective of p53 status and chemo-sensitivity in epithelial ovarian cancer cells

The CG portion of GSH anchors the two adjacent protomers via not only these salt bridges, but also by additional H-bonding interactions with Y231 of protomer A and the carbonyl oxygen of W154 of protomer B via a bridging water molecule

Li H, Zhu XR, Zhang L, Dong L, Tung S, Ahamad A, Chao KS, Morrison WH, Rosenthal DI, Schwartz DL, Mohan R , Garden AS

By combining the structural and drug delivery advantages of hydrogels with the unique physicochemical properties of nanoparticles, these hybrid systems potentially enable simultaneous organ protection, radiosensitization, and TME modulation