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These harmful chemicals accumulate in the fatty tissue of a few fish, and consuming such contaminated fish causes multiple health disorders in the human body, such as cancer (82)

The carotenoid may block substances leading to inflammation

Studies using exogenous oxidants such as tert -butyl hydroperoxide (tBH) and hydrogen peroxide (H 2 O 2 ) in cultured RPE cells highlight the role of oxidative stress in RPE cell death and premature senescence 8,9,10,11

These discrepancies might be explained and reconciled by recent studies, which demonstrated that after amino acid deprivation, the proteasome moves from its predominant location in the nucleus to the cytoplasm, promoting protein degradation in the cytoplasm and thereby supplying the amino acids necessary for cell survival