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Science 269 : 17371740

Khanim, F.L

Abstract Numerous regulatory peptides play a critical role in the pathogenesis of airway inflammation, airflow obstruction and hyperresponsiveness, which are hallmarks of asthma

The findings that loss of claudin-7 expression induces sloughing of intestinal epithelial cells (claudin-7 KO mice), possibly by disrupting the complex between claudin-1, claudin-7 and 1-integrin, highlights the previously underappreciated roles of TJ proteins in cellmatrix interactions