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Furthermore, this approach enhances the therapeutic efficacy of the AR antagonist enzalutamide, suggesting PDIA1/PDIA5 may represent potential therapeutic targets for prostate cancer ( 4.2 Disulfidptosis in testicular and bladder cancers In testicular cancer, especially seminoma tumors, high SLC7A11 protein expression and mRNA levels are often observed, which may be associated with the proliferation, survival, and initial response to chemotherapy (cisplatin) of certain subtypes, or their unique metabolic reprogramming and oxidative stress states ( Studies have shown that the expression of SLC7A11 differs significantly in different molecular subtypes and clinical stages ( in vivo experiments, and even reverse cisplatin resistance ( In summary, although the research on disulfidptosis in testicular cancer and bladder cancer is in its infancy, the revelation of its molecular mechanism has attracted widespread attention

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