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Journal of Pharmacology and Experimental Therapeutics, 377(3), 417-440

H.YeungC

Mechanistically, EPA and DHA integrate into platelet membranes and displace arachidonic acid, thereby shifting the eicosanoid balance toward increased prostacyclin (PGI 2 ) and reduced thromboxane A 2 (TXA 2 ) synthesis (248)