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In severe cases, not being able to urinate at all (a medical emergency)

The bifunctional complex according to item 146, wherein each ring system is independently selected from the group consisting of aryl, heteroaryl, cycloalkyl, heterocycloalkyl, cycloalkenyl, and heterocycloalkenyl, wherein each of said ring systems can independently be substituted or unsubstituted, such as having from about four to about ten, for example from about four to about thirteen, or from about four to about fourteen ring atoms

In contrast, no mature cataracts were found in young adult VEGFA hyper mice (no mature cataract was observed in 50 VEGFA hyper mice that were up to 3 months old) (Fig 4A and Appendix Fig S1)

The stability data, illustrated in Fig