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Thus, the etiology of primary cerebral folate deficiency includes the presence of autoantibodies against the folate receptor (FR1) and mutations in the FOLR1 gene, which encodes the FR1 protein [101]

If the MMA levels are elevated that means you are deficient in Vitamin B12, but more specifically you are deficient in adenosylcobalamin which is a specific form of B12 for energy and mitochondria function so supplementation with methylcobalamin may not be the best way to improve this