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doi: 10.1083/jcb.201010065

Emerging concepts of mitochondrial dysfunction in Parkinsons disease progression: pathogenic and therapeutic implications

Your plasma volume starts rising in the first trimester and peaks near delivery at roughly 48% above your pre-pregnancy baseline, according to a PMC systematic meta-analysis of 347 pregnancies

Furthermore, cytokines released by astrocytes may bind to their specific receptors in the dopaminergic neurons, such as TNFR1 and 2, and activate proapoptotic mechanisms through the activation of caspase 3, caspase 8, and cytochrome c [10]