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[DOI] [PMC free article] [PubMed] [Google Scholar] 413.Karkhaneh R, Faghihi H, Riazi-Esfahani H, Abrishami M, Bazvand F, Ebrahimiadib N, et al

Furthermore, at the tested concentration range (0.2 and 2.0 M), low binding to blood cells and preferential distribution into the plasma were observed with no concentration-dependency, in agreement with the in vivo results described above, and driven by high binding to plasma proteins

(But) over the last year or two, the studies that have come back really have not shown benefit from doing supplemental vitamin D. Taking too much vitamin D can cause problems such as constipation and nausea and, in more serious cases, kidney stones and kidney damage

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