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In complementary studies, depletion of MFN1/2 found similar hyperglycemia, reductions in insulin secretion, and mitochondrial network fusion and respiration, however, these effects correlate more with effects on mitochondrial DNA (mtDNA) content rather than changes in fission/fusion (Sidarala et al., 2022)

Proteasome activation delays aging in vitro and in vivo

FcRn binding to HA-Fc fusions in ELISA 96-well EIA/RIA plates (Corning) were coated with a recombinant human albumin variant (8 g/mL in PBS/ 100 L per well) engineered to bind pH independently to human FcRn 29