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191 YinL.LundinB.BertrandM.NurmiM.SolymosiK.KangasjarviS.et al (2010)

Cortisol can lead to an increase in the permeability of the intestinal barrier and allow the transfer of bacteria and pro-inflammatory compounds into the blood (206)

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Molecular docking has identified glutamate dehydrogenase 2 (GLUD2) as a key target, with 27 bioactive THH components (wilforine, wilfordine) binding strongly to its active site (PDB ID: 6G2U)