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The research rationale for combination use is the complementary, non-overlapping mechanisms of the combined compounds

At picomolar to nanomolar concentrations, GHK-Cu stimulated the synthesis of collagen in skin fibroblasts, increased accumulation of total proteins, glycosaminoglycans (in a biphasic curve) and DNA in the dermal wounds in rats

GHK-Cu, also known as copper tripeptide-1, directly stimulates collagen and elastin production at the cellular level

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