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Transgenic mouse models such as the mouse model over-expressing full-length, WT -syn show significant deficits in motor tests, such as deficits in orientation and coordination in the pole test (Fleming et al., 2018)

Heat shock proteins respond to protein damage caused by oxidative stress following exposure to a diverse set of environmental stressors ( Hsp70 has been linked to response to heavy metal stress in bacteria, plants, nematodes, and fish (Williams et al., 1996