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Although high selectivity of PAG for CSE over CBS has been reported (i.e., an IC 50 of 40 M for the CSE-catalyzed reaction using 1 mM of cysteine as the substrate, with no detectable inhibition of CBS even at 10 mM PAG), it also inhibits several other PLP enzymes, such as aspartate aminotransferase, alanine aminotransferase, and methionine -lyase (Sun et al., 2009)

Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, et al

DNMT1-mediated PPAR methylation aggravates damage of retinal tissues in diabetic retinopathy mice

Among other functions, CK2 plays a vital role in many oncogenic signaling pathways such as the PI3K/AKT [52], IKK (IB) kinase/NF-B [53], and JAK/STAT pathways [54]