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Symptoms of lupus nephritis include: High blood pressure Swelling of the hands, ankles, feet, legs, or face Changes in urination (blood or foam in urine, increased nighttime urination frequency, pain or trouble urinating) High levels of creatinine in the blood Blood Disorders Lupus can cause problems with the blood, too, including anemia, or low red blood cell count

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This deficiency can lead to megaloblastic anemia, where the body produces large, abnormal red blood cells that cannot function effectively, resulting in symptoms such as fatigue, weakness, and neurological issues