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However, additional data was gathered with the knockout mice that indicated that while AOD9604 did not lead to significant weight loss or increase in lipolysis without the beta(3)-adrenergic receptors, there was an increase in energy expenditure and fat oxidation

H., Kang, Y

Understanding the specific effects reported helps set realistic expectations and allows for informed monitoring during treatment protocols

The extent of inhibition of ACE is calculated using the E max model, where E max , the maximum extent of inhibition, is 100% and the C 50 , the concentration of the drug that produces 50% of maximum effect, is about 1 ng/mL