glutathione detection patent peroxidase 2 is a metabolic driver of the tumor immune microenvironment and immune checkpoint inhibitor response An engineered cysteine sensor optimized

Glutamate both in neurons and glial cells is synthesized through the tricarboxylic acid cycle and additionally in neurons by the glutamateglutamine cycle, where it is accumulated in vesicles for future release

Bubenik, G

Bronchial thermoplasty: reappraising the evidence (or lack thereof)

This oxidative environment causes mtDNA lesions, mutations, and deletions ( Tat (transactivator of transcription) protein, even in the absence of productive infection, can enter mitochondria and inhibit the expression and function of TFAM (Mitochondrial transcription factor A), thereby impairing mtDNA replication and transcription and reducing the expression of mtDNA-encoded ETC subunits ( 4.3 Consequences of mtDNA damage: from bioenergetic crisis to immune exhaustion mtDNA mutations and depletion impair the synthesis of essential ETC components, resulting in defective OXPHOS, reduced ATP synthesis, collapse of the mitochondrial membrane potential (m), and accumulation of metabolic intermediates due to TCA cycle disruption and compensatory glycolysis