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Author contributions AH and DC conceived and designed the experiments

It is particularly common in individuals with certain risk factors, including those who have undergone gastric or small intestine resections, have inflammatory bowel disease, use metformin or proton pump inhibitors, follow a vegan diet, or are older than 75 years

Comparing human cadaveric ACL, patellar tendon, and semitendinosus tendon, ACLs were found to have a larger total number of enzymatic crosslinks than either tendons and no differences were observed between patellar tendon and semitendinosus tendon (Suzuki et al ., 2008)

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