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Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise

Lotiglipron was discontinued in 2023 owing to unfavourable pharmacokinetic drug-drug interaction data from two Phase I studies and to elevated transaminases indicative of liver dysfunction in a subset of patients 24

PMID: 65 LfgrenLPehrssonSHgglundGTjellstrmHNylanderS

Swett JE, Woolf CJ (1985) The somatotopic organization of primary afferent terminals in the superficial laminae of the dorsal horn of the rat spinal cord