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Measurement of oxidative stress in PsA coincubated with neutrophils To assess oxidative stress in bacteria phagocytized by neutrophils, we measured reduced to oxidized glutathione ratio in PsA coincubated with neutrophils following a previously described method 55

The adverse effects of diabetes extend beyond the endothelium, as hyperglycemic conditions impact microglia activation, leading to increased proinflammatory cytokine production and ROS formation in both the endothelium and parenchymal microglia

For example, GPX4, a key factor in the antioxidant system, also inhibits apoptosis and necroptosis to protect cells from various insults [129, 130]

There it also inactivates reactive intermediate products resulting from the metabolisation of certain drugs