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Relevant to the connection between oncogenic STAT3 and aberrant lipid metabolism, it has been shown that STAT3-activated CD36 contributes to fatty acid uptake in chronic lymphocytic leukemia cells (106), which supports a critical role of STAT3 in the regulation of CD36-dependent leukemia

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Therefore, further research is warranted to clarify the role of HSP70 in rIPC-induced renal protection, including its regulatory mechanisms and potential therapeutic implications (Figure 4)