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Hepatocellular carcinoma: recent advances and emerging medical therapies

Corroborating these findings, both FTH and FTL overexpression have also been implicated in chemotherapy resistance across various tumor types and chemotherapeutic agents (reviewed in ref

Simuni T, Fiske B, Merchant K, Coffey CS, Klingner E, Caspell-Garcia C, et al

Sido et al, 1998), the increase in -GCS in mucosa from TNBS-treated rats can be interpreted as an adaptive response to control the consequences of the stress induced by TNBS as -GCS-HS is known to be upregulated in response to divergent stressful conditions including oxidative stress or GSH depletion (Morales et al, 1997, 1998